Effect of Garlic Powder on Lipid Metabolism in Stroke-prone Spontaneously Hypertensive Rats.
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- OGAWA Hiroshi
- Department of Hygiene, Kinki University School of Medicine
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- SUEZAWA Kazunori
- Department of Hygiene, Kinki University School of Medicine
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- MEGURO Tadamichi
- Department of Hygiene, Kinki University School of Medicine
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- SASAGAWA Sukenari
- Research Institute for Life Science, Kinki University
Bibliographic Information
- Other Title
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- ガーリック粉末投与がSHRSP(脳卒中易発症性高血圧自然発症ラット)の脂質代謝に及ぼす影響
- ガーリック フンマツ トウヨ ガ SHRSP ノウソッチュウ イハッショウセイ
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Description
The effect of garlic powder on lipid metabolism was studied using stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model. The animals (5 weeks old) were fed a standard diet containing garlic powder (1% for 3 weeks and 3% for an additional 3 weeks). The effects of garlic powder administration were as follows. 1) The increase in blood pressure was significantly prevented. 2) The content of apoE in the LDL and HDL fractions tended to increase, although changes in the levels of lipid and apolipoproteins in the serum were not observed. This suggests an increase in apoEHDL, which plays an important role in reverse cholesterol transport. 3) Cholesterol 7 α-hydroxylase activity increased significantly, while acyl-CoA: cholesterol acyltransferase (ACAT) activity tended to decrease. These results indicate that garlic powder may exert some beneficial effect on lipoprotein metabolism and could be effective for preventing hyperlipidemia.
Journal
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- Nippon Eiyo Shokuryo Gakkaishi
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Nippon Eiyo Shokuryo Gakkaishi 46 (5), 417-423, 1993
Japan Society of Nutrition and Food Science
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Details 詳細情報について
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- CRID
- 1390001206294165888
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- NII Article ID
- 130000853956
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- NII Book ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL BIB ID
- 3856270
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed