Suppressive effect of dexamethasone on morphihe-induced adrenocorti-coidogenesis in rat

DOI Web Site Web Site PubMed
  • KUWAMURA TSUKASA
    Department of Pharmacology, The Jikei University School of Medicine
  • NAGAO SHIGEYUKI
    Department of Pharmacology, National Institute of Hygienic Sciences
  • NAKAURA SHINSUKE
    Department of Pharmacology, National Institute of Hygienic Sciences
  • KAWASHIMA KUNIO
    Department of Pharmacology, National Institute of Hygienic Sciences
  • TANAKA SATORU
    Department of Pharmacology, National Institute of Hygienic Sciences
  • OMORI YOSHIHITO
    Department of Pharmacology, The Jikei University School of Medicine
  • NAKAO TAKESHI
    Department of Pharmacology, The Jikei University School of Medicine

書誌事項

タイトル別名
  • Suppressive Effect of Dexamethasone on Morphine-Induced Adrenocorticoidogenesis in Rat

この論文をさがす

説明

The effect of morphine on adrenal-pituitary axis function was examined by determination of adrenal and serum corticosterone changes in rats pretreated with dexamethasoe.<BR>Increases in both adrenal and serum corticosterone concentrations induced by a single dose of 20mg/Kg of morphine were almost completely inhibited by subcutaneous injection with 1mg/rat of dexamethasone 3 hr prior to morphine administration. However, no suppressive effect of dexamethasone was observed when a dose of 30μg/rat of synthetic ACTH was given.<BR>In morphinized rats, adrenal and serum corticosterone concentrations were not so significantly increased as observed in a single dose of morphine administration. However, corticosterone concentrations after the morphinization were increased strikingly by synthetic ACTH or nalorphine administration immediately after the final treatment of morphine. But these increases after nalorphine administration were inhibited entirely by the pretreatment with dexamethasone.<BR>On the bases of these findings, it was suggested that morphine dose not act directly corticoidogenesis in adrenal cortex but affects through the central nervous system.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ