[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Ghrelin in small intestine, its contribution to regulation of food intake and body weight in cross-intestinal parabiotic rats

  • Noguchi Hitoshi
    Noguchi Thyroid Clinic and Hospital Foundation, Beppu 874-0932, Japan
  • Masaki Takayuki
    Oita University School of Medicine, Internal Medicine 1, Yufu 879-5593, Japan
  • Kakuma Tetsuya
    Oita University School of Medicine, Internal Medicine 1, Yufu 879-5593, Japan
  • Nakazato Masamitsu
    Miyazaki University School of Medicine, Internal Medicine 3, Miyazaki 889-1692, Japan
  • Yoshimatsu Hironobu
    Oita University School of Medicine, Internal Medicine 1, Yufu 879-5593, Japan

Search this article


Ghrelin has been shown to be associated with feeding behavior in humans and rodents. It has been suggested that ghrelin may play a role behind the effect of bariatric surgery. Inbred rats were made into parabiotic pairs so that they shared a single abdominal cavity. A further operation is performed later in which the small intestines are transected and re-connected so that one rat continually lost nutrition to its partner. Changes in food intake and body weight were recorded. Seven weeks later, content of ghrelin in the plasma, stomach and upper intestines were measured in the paired rats. Rats which lost nutrients to its counterpart (Loss rats) ingested significantly more food than sham control rats (p<0.001). Rats which gained nutrient (Gain rats) ingested less than controls (p<0.001). There was no significant difference in body weight, blood glucose, insulin, free fatty acids and triglycerides between the paired rats. There was significantly higher levels of ghrelin in the plasma (p<0.008) and the intestine of the Loss rats (p<0.02). There were no difference in ghrelin in the stomach between parabiotic rats and sham operated controls. The ghrelin content of the plasma and intestines were significantly higher in the Loss rats, which ate more, and normal in the Gain rats, which ate less than controls. Because no remarkable changes in the ghrelin content were observed in the stomach, difference in the quality of the chime may affect the local synthesis and release of ghrelin.


  • Endocrine Journal

    Endocrine Journal 58 (8), 625-632, 2011

    The Japan Endocrine Society

Citations (0)*help

See more


See more

Related Articles

See more

Related Data

See more

Related Books

See more

Related Dissertations

See more

Related Projects

See more

Related Products

See more


Report a problem

Back to top