Ghrelin in small intestine, its contribution to regulation of food intake and body weight in cross-intestinal parabiotic rats

DOI Web Site PubMed 参考文献54件
  • Noguchi Hitoshi
    Noguchi Thyroid Clinic and Hospital Foundation, Beppu 874-0932, Japan
  • Masaki Takayuki
    Oita University School of Medicine, Internal Medicine 1, Yufu 879-5593, Japan
  • Kakuma Tetsuya
    Oita University School of Medicine, Internal Medicine 1, Yufu 879-5593, Japan
  • Nakazato Masamitsu
    Miyazaki University School of Medicine, Internal Medicine 3, Miyazaki 889-1692, Japan
  • Yoshimatsu Hironobu
    Oita University School of Medicine, Internal Medicine 1, Yufu 879-5593, Japan

この論文をさがす

抄録

Ghrelin has been shown to be associated with feeding behavior in humans and rodents. It has been suggested that ghrelin may play a role behind the effect of bariatric surgery. Inbred rats were made into parabiotic pairs so that they shared a single abdominal cavity. A further operation is performed later in which the small intestines are transected and re-connected so that one rat continually lost nutrition to its partner. Changes in food intake and body weight were recorded. Seven weeks later, content of ghrelin in the plasma, stomach and upper intestines were measured in the paired rats. Rats which lost nutrients to its counterpart (Loss rats) ingested significantly more food than sham control rats (p<0.001). Rats which gained nutrient (Gain rats) ingested less than controls (p<0.001). There was no significant difference in body weight, blood glucose, insulin, free fatty acids and triglycerides between the paired rats. There was significantly higher levels of ghrelin in the plasma (p<0.008) and the intestine of the Loss rats (p<0.02). There were no difference in ghrelin in the stomach between parabiotic rats and sham operated controls. The ghrelin content of the plasma and intestines were significantly higher in the Loss rats, which ate more, and normal in the Gain rats, which ate less than controls. Because no remarkable changes in the ghrelin content were observed in the stomach, difference in the quality of the chime may affect the local synthesis and release of ghrelin.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 58 (8), 625-632, 2011

    一般社団法人 日本内分泌学会

参考文献 (54)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ