GLUTAMIC DECARBOXYLASE AND γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE ACTIVITIES DURING AND ON SUPRESSION OF THE RUNNING FIT

NISHIZAWA YOSHITO, KODAMA TEISUKE, KOBAYASHI SHIGEO

doi:10.5925/jnsv1954.5.241

GLUTAMIC DECARBOXYLASE AND γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE ACTIVITIES DURING AND ON SUPRESSION OF THE RUNNING FIT

DOI PubMed 被引用文献1件オープンアクセス

NISHIZAWA YOSHITO

Department of Pediatrics, Faculty of Medicine, Osaka University
KODAMA TEISUKE

Department of Pediatrics, Faculty of Medicine, Osaka University
KOBAYASHI SHIGEO

Department of Pediatrics, Faculty of Medicine, Osaka University

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説明

1. Brain glutamic decarboxylase is inhibited in the OMP-induced running fit, but γ-aminobutyric-α-ketoglutaric transaminase is not inhibited. 2. Both enzymes show normal activities when the seizure is prevented by pyridoxine. 3. MAAMP inhibits γ-aminobutyric-α-ketoglutaric transaminase to a greater extent than glutamic decaboxylase. 4. In preventing the OMP running fit with MAAMP, it is more effective to give it before OMP. 5. The inhibition of glutamic decarboxylase by OMP is slighter when the running fit is prevented by MAAMP. 6. Both glutamic decarboxylase and γ-aminnobutyric-α-ketoglutaric transaminase are inhibited in the thiosemicarbazide-induced running fit, but when the seizure is prevented by pyridoxine, there is no inhibition. 7. From these results, it is assumed that brain aminobutyric acid is decreased when the running fit occurs but is not reduced when the running fit is prevented by pyridoxine.