子宮内膜のＤＮＡ合成に及ぼす卵巣ホルモンの影響　　卵巣摘出ラット子宮内膜におけるエストロゲン投与とＤＮＡ合成能の関係

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タイトル別名
  • Effect of ovarian hormones on DNA synthesis in uteline endometorium
  • シキュウ ナイマク ノ DNA ゴウセイ ニ オヨボス ランソウ ホルモン ノ
  • 卵巣摘出ラット子宮内膜におけるestrogen投与とDNA合成能の関係

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Autoradiographic study using 3H-6-thymidine was carried out to investigate the effect of estrogen on the induction of DNA synthesis in uterine endometorium of ovaryectomized rats. Wistar strain rats weighing about 200 g were ovaryectomized, and 16 days later, a single dose of estradio1-17β was intramuscularly administered.<BR>1) 3H-6-thymidine uptake by the endometorium after a single injection of 10 μg estradiol-17β was determined by in vivo and in vitro methods, and there was no difference between the two.<BR>2) DNA synthesis was specifically increased in the surface epithelium after administration of estradiol-17β but no significant increase was observed both in stroma and glandular epithelium.<BR>3) Change of the 3H-6-thymidine up take after a single injection of estradio1-17 β was examined, the maximum up take was detected 24 h after the injection.<BR>4) A dose of 10 μg estradio1-17 β could induced the maximum up take of the labelled thymidine by the surface epithelium.

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