Molecular Cloning and Characterization of Porcine Homeodomain Transcription Factor Msx1
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- ISHIKAWA Akio
- Division of Life Science, Graduate School of Agriculture, Meiji University
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- KATO Takako
- Institute of Reproduction and Endocrinology, Meiji University
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- SUSA Takao
- Division of Life Science, Graduate School of Agriculture, Meiji University
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- SANO Akiko
- Division of Life Science, Graduate School of Agriculture, Meiji University
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- KATO Yukio
- Division of Life Science, Graduate School of Agriculture, Meiji University Department of Life Science, School of Agriculture, Meiji University Institute of Reproduction and Endocrinology, Meiji University
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We cloned a porcine ortholog of homeodomain transcription factor Msx1 from the porcine pituitary cDNA library. The amino acid sequence of Msx1 shows high conservation among mammalian species. RT-PCR for porcine fetal and postnatal pituitaries showed that Msx1 is already expressed at early fetal day 40, decreases to a low level before birth and then remarkably decreases after birth. On the other hand, Msx1 expression was observed in all pituitary-derived cell line tested, with most in a gonadotrope lineage LβT4. Transfection assay demonstrated that Msx1 markedly repressed the basal Cga and Fshb gene expression, while Lhb expression was affected slightly. Taken together, Msx1 may play a role in repressing gene expression in the fetal and postnatal periods.<br>
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 55 (3), 278-282, 2009
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001206336126976
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- NII論文ID
- 10024942371
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- NII書誌ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 10257849
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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