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- 山本 誠
- 金沢大学医学部第二内科学教室
書誌事項
- タイトル別名
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- SALIVARY AND PANCREATIC AMYLASE CLEARANCE TO CREATININE CLEARANCE RATIOS IN PATIENTS WITH CHRONIC RENAL FAILURE
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説明
Salivary and pancreatic amylase clearance to creatinine clearance ratios in 19 patients with chronic renal failure, were compared with those obtained for normal control subjects.<br>Hyperamylasemia was frequently observed. Both serum salivary and pancreatic amylase levels were elevated in most patients. The highest serum amylase activity was 774IU/L, less than 2 times value of normal upper limit.<br>Amylase clearance (0.42±0.24 ml/min) was reduced markedly in chronic renal failure. Salivary and pancreatic amylase clearances changed in parallel to that of total amylase, but these clearances were by different ratios reduced to about one fifth (0.30±0.18ml/min, salivary) and one seventh (0.53±0.32 ml/min, pancreatic) of those in controls. Normal control values were 2.45±0.73ml/min (total), 1.45±0.68ml/min (salivary) and 3.69±1.01ml/min (pancreatic), respectively.<br>Amylase clearance to creatinine clearance ratio of the patients with chronic renal failure (4.47±2.84%) was significantly higher (p<0.05) than that in controls (2.60±0.59%). The clearance ratio for salivary amylase (3.48±2.87%) was also significantly higher (p<0.01) than in controls. But this ratio for pancreatic amylase (5.33±2.81 %) was not significantly higher. Corresponding control values were 1.52±0.46% (salivary) and 3.96±0.97% (pancreatic).<br>Of the nine patients who showed raised clearance ratios, eight had less than 10ml/min of creatinine clearance value and one had 10.2ml/min. Amylase clearance to creatinine clearance ratio in chronic renal failure was inversely related to creatinine clearance (r=-0.5587, p<0.05). All patients studied did not have clinical evidence of pancreatic disease, indicating that in the presence of severe chronic renal failure a high clearance ratio need not be indicative of acute pancreatitis.<br>These results are compatible with the suggestion that in severe renal failure the loss of nephrons results in decreased fractional reabsorption of amylase in the tubules.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 77 (2), 246-255, 1980
一般財団法人 日本消化器病学会
