Blood Concentration of Food-Derived Peptides follwing Oral Intake of Chicken Collagen Hydrolysate and its Angiotensin-Converting Enzyme Inhibitory Activity in Healthy Volunteers

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  • 鶏コラーゲン加水分解物摂取後のヒト血中ペプチドの動態とＡＣＥ阻害作用
  • トリ コラーゲン カスイ ブンカイ ブツ セッシュ ゴ ノ ヒト ケッチュウ ペプチド ノ ドウタイ ト ACE ソガイ サヨウ
  • Blood concentration of food-derived peptides following oral intake of chicken collagen hydrolysate and its angiotensin-converting enzyme inhibitory activity in healthy volunteers

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Abstract

In this study, we investigated the concentration of food derived-peptides in blood following oral intake of chicken collagen hydrolysate (chicken-collagen octa peptides ; C-COP) and measured the angiotensin-converting enzyme (ACE) inhibitory activity of these peptides. Healthy volunteers ingested the C-COP solution (25g/60kg body weight) after fasting for 12h. The peptide-formed hydroxyproline (Hyp) significantly increased and reached maximum levels (91.1μM) 2h after consumption. Pro-Hyp, Leu-Hyp, Pro-Hyp-Gly, Phe-Gly, Ala-Hyp, Hyp-Gly, Glu-Hyp-Gly, Ala-Hyp-Gly and Ser-Hyp-Gly were detected in human blood, possessing ACE-inhibitory activity. Of them, Ala-Hyp (IC50 : 0.177mM) had the strongest ACE inhibitory activity. Thus, C-COP appears to absorb with the peptides by enzymatic digestion in blood, thereby inhibiting ACE, suggesting that food-derived collagen peptides are related to antihypertensive effects.

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