Hypocholesterolemic Activity in Lactic Acid Bacteria Isolated from Funazushi

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  • ふなずしからのコレステロール低下作用を有する乳酸菌の分離
  • フナズシ カラノ コレステロール テイカ サヨウ オ ユウスル ニュウサンキン ノ ブンリ

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The hypocholesterolemic activities of Lactobacillus and Pediococcous isolated from Funazushi, a fermented-fish product, were evaluated with in vitro and in vivo assay systems. Among viable cells, we selected Lactobacillus plantarum NLB136 for its strong cholesterol and bile acid binding abilities, as well as for its tolerance against a simulated gastric juice and its lack of bile acid deconjugation activity. Among the heat-sterilized bacteria, we selected L. paracasei NLB162 and NLB163 for their strong cholesterol and bile acid binding abilities. The heat-sterilized L. paracasei NLB163 showed the strongest hypocholesterolemic activity in cholesterol-fed mice, indicating that the heat-sterilized L. paracasei NLB163 could be a new functional food material with hypocholesterolemic efficacy.

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