Lactic Fermented Soymilk Improves Hepatic Lipid Metabolism in Rats Fed a High Fat and High Cholesterol Diet

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  • Hirahata Rie
    Food Science and Nutrition Major, Graduate School of Human Environmental Sciences,Mukogawa Women’s University
  • Kobayashi Maki
    Department of Food Science and Nutrition, School of Human Environmental Sciences
  • Egusa Shintaro
    Research Development Division, Marusan-ai Co., Ltd.
  • Sakakibara Rie
    Research Development Division, Marusan-ai Co., Ltd.
  • Fukuda Mitsuru
    Department of Food Science and Nutrition, School of Human Environmental Sciences

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  • 乳酸発酵豆乳は高脂肪高コレステロール食投与ラットの肝臓脂質代謝機能を改善する
  • ニュウサン ハッコウ トウニュウ ワ コウシボウ コウコレステロールショク トウヨ ラット ノ カンゾウ シシツ タイシャ キノウ オ カイゼン スル

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Abstract

We investigated the effect of lactic fermented soymilk in improving hepatic lipid metabolism in rats fed a high fat and high cholesterol diet. Male Sprague-Dawley rats, aged 7 weeks, were fed a very high lipid diet (VC diet) or moderately high lipid diet (MC diet) for 5 weeks. The VC diet contained 30 % triacylglycerol (TG) and 0.5 % cholesterol ; for VF diet (very high lipid diet with fermented soymilk), 25.0 % of the VC diet was replaced with fermented soymilk. The MC diet contained 15 % TG and 0.125 % cholesterol ; for MF diet (moderately high lipid diet with fermented soymilk), 22.2 % of the MC diet was replaced with fermented soymilk. Only hepatic crude lipid and cholesterol contents were significantly suppressed in the VF group, whereas plasma total cholesterol (TC) and TG levels, as well as hepatic crude lipid, cholesterol and TG contents were significantly suppressed in the MF group. There was no down-regulation of hepatic lipid metabolism-related gene expression in the VF group ; in contrast, the expression of FAS was down-regulated in the MF group. These results suggested that the effect of fermented soymilk in improving lipid metabolism was small in rats fed the VC diet, likely due to reduced hepatic metabolic function caused by lipid overloading, whereas ingestion of fermented soymilk effectively suppressed the accumulation of hepatic lipid and the elevation of plasma lipid levels in rats fed a MC diet.

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