リポタンパクモデルとしての脂質エマルション表面膜の 性質と細胞との相互作用(動脈硬化の発生)

書誌事項

タイトル別名
  • Lipid Emulsions Used as Models for Lipoproteins
  • リポタンパク モデル ト シテ ノ シシツ エマルション ヒョウメン マク ノ セイシツ ト サイボウ ト ノ ソウゴ サヨウ ドウミャク コウカ ノ ハッセイ

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抄録

Plasma lipoproteins play important roles for lipid homeostasis. Lipoproteins contain triglycerides and cholesteryl ester in the core. The lipoprotein surface is formed by phospholipids and cholesterol, and various apolipoproteins are bound to the surface of lipoprotein particles. Lipid emulsion particles have been used as models for plasma lipoproteins. The lipid emulsions are prepared by the method using a high pressure emulsifier. Compared with plasma lipoproteins, it is easy to alter the lipid composition of emulsion particles and apolipoproteins bound to emulsion surface. Various lipids and proteins affect the lipoprotein metabolism, and are associated with hyperlipidemia and atherosclerosis. However, the roles of many components of lipoprotein particles are still uncertain. Therefore, lipid emulsions are useful for examining the mechanism of hyperlipidemia and atherosclerosis.

収録刊行物

  • 膜 32 (1), 11-17, 2007

    日本膜学会

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