Haemophilus paragallinarum の莢膜抗体と莢膜抗原の感染防御能

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  • Relationship between anticapsular antibody and protective activity of a capsular antigen of Haemophilus paragallinarum.
  • Haemophilus paragallirarumの抗莢膜抗体と莢膜抗原の感染防御能〔英文〕
  • Haemophilus paragallirarum ノ コウ キョウマク コ

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Relationship between anticapsular antibody and protective activity of a capsular antigen of Haemophilus paragallinarum serotype HA-1 strain 221 was investigated. A capsular antigen was extracted from encapsulated organisms of the hi variant by various procedures. Indirect hemagglutination (IHA) test was used for detecting anticapsular antibodies. The IHA antibodies against a formalin-saline-extracted and phenol-treated antigen prepared with hi variant (hi-FSEx-P antigen) were specifically found in hi-NT antisera prepared from nontreated (NT) antigens of hi variant, and IHA activity of the antibodies found in hi-NT antiserum was specifically inhibited by the hi-FSEx-P antigen. The capsular antigen was found to be heat-stable and hyaluronidase-resistant. Chicks injected intravenously with hi-FSEx-P antigen produced anticapsular antibodies, and protection against the challenge exposure with 221-hi organisms was not observed in these chicks despite the presence of IHA antibodies. The results showed that protective activity of H. paragallinarum dose not reside in a capsular antigen, and that anticapsular antibody formation significantly depends on a route of injection and on ages of chicks.

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