遺伝性腎疾患モデル(ICGN)マウス肝臓におけるエリスロポエチン産生細胞の同定
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- YAMAGUCHI-YAMADA Misuzu
- Laboratory of Neurophysiology, National Institute for Basic Biology
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- AKASHI Naotsugu
- Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
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- GOTO Yasufumi
- Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
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- ANAN Sayuri
- Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
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- YAMAMOTO Yoshie
- Department of Veterinary Sciences, National Institute of Infectious Diseases
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- OGURA Atsuo
- Bioresource Center, RIKEN
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- MANABE Noboru
- Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
書誌事項
- タイトル別名
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- Erythropoietin-Producing Cells in the Liver of ICR-Derived Glomerulonephritis (ICGN) Mice
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抄録
The ICR-derived glomerulonephritis (ICGN) mouse is an appropriate model for anemia associated with chronic renal disorder (CRD). Insufficient renal production of erythropoietin (EPO) induces the anemia associated with CRD. EPO mRNA is expressed in both kidneys and liver of progressing-stage ICGN mice. Hypoxic stimulation induced the EPO mRNA expression in the liver as well as in the kidneys of ICGN mice. The localization of EPO-producing cells in the liver remains controversial. Present study using an amplified in situ hybridization technique identified that nonparenchymal cells were the source of hepatic EPO production in ICGN mice under both normoxia and hypoxia.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 68 (1), 65-68, 2006
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206426998656
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- NII論文ID
- 130000448087
- 110004675694
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 7809056
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可