Increased generation of superoxide in erythrocytes infected with Bebesia gibsoni
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- OTSUKA Yayoi
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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- YAMASAKI Masahiro
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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- YAMATO Osamu
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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- MAEDE Yoshimitsu
- Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
書誌事項
- タイトル別名
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- Increased Generation of Superoxide in Erythrocytes infected with Babesia gibsoni.
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抄録
The present study was conducted to clarify the mechanism underlying the oxidative process in erythrocytes infected with Babesia gibsoni. The parasite B. gibsoni was cultured together with erythrocytes from normal dogs for 7 days. When parasitemia reached 12.0-13.4% at Day 7, the production of superoxide in erythrocytes was significantly higher in the parasitized culture than in the control culture (p<0.005). The concentration of thiobarbituric acid reactive substances (TBARS) in erythrocytes in parasitized culture was also significantly increased compared with the control culture (p<0.005), indicating that lipid peroxidation was greater in infected erythrocytes than in non-infected cells. In addition, the rates of superoxide generation in the blood of B. gibsoni-infected dogs were also significantly higher than in non-infected dogs (p<0.001). These results indicate that superoxide anions are increased in erythrocytes parasitized with B. gibsoni, and suggest that oxidative damage, due to lipid peroxidation, might be caused in host erythrocytes by the parasite.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 63 (10), 1077-1081, 2001
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206427063296
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- NII論文ID
- 110003920751
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXptVertrY%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 5953731
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- PubMed
- 11714022
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可