ゴールデンハムスターにおける姉妹染色分体交換に関する研究　実験的担癌体末梢血リンパ球による検討

DOI
  • 坂井 広也
    新潟大学歯学部口腔外科学第二講座 新潟大学歯学部口腔病理学講座

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タイトル別名
  • Sister chromatid exchange of golden hamster. On the lymphocytes in experimental malignant tumor.
  • On the lymphocytes in experimental malignant tumor
  • 実験的担癌体末梢血リンパ球による検討

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The incidence of spontaneous and mitomycin C (MMC)-induced sister chromatid exchange (SCE) was investigated in peripheral lymphocytes of 7 male golden hamsters bearing transplanted squamous cell carcinoma in the cheek pouch and 7 normal controls. The results are summarized as follows.<BR>1. Both tumor bearing and control groups were sensitive to SCE induction by MMC.<BR>2. The mean incidence of spontaneous SCE in the tumor bearing group (7.65±0.78) was significantly higher (Wilcoxon, P<0.005) than that in the control group (5.72±0.41).<BR>3. The mean incidence of SCE induction by 5 ng/ml of MMC was 16.0 ±1.73 in the tumor bearing group and 12.29±1.38 in the controls. The corresponding values at a dose of 10 ng/ml of MMC were 20.39±1.38 and 17.36±1.14, respectively. The incidence of SCE in the tumor bearing group was significantly higher (P<0.005) than that in the control group at either dose of MMC.<BR>The results suggest that peripheral lymphocytes of the golden hamster are useful for investigating SCE, and that SCE could be used as a preclinical parameter to predict the presence of malignant tumor.

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