ペーパークロマトグラフイーによる尿中アミノ酸の研究

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タイトル別名
  • Studies on Urinary Amino-Acids by Paper Partition Chromatography
  • ペーパークロマトグラフイー ニ ヨル ニョウチュウ アミノサン ノ ケンキュウ

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Amino-acids in urine were analyzed by means of paper partition chromatograph, both clinically and experimentally.<br>Usually two-dimension method is performed, but it is also of some clinical value to detect amino-acids with large Rf by the use of one dimension method.<br>Alanine, Glycine and Taurine always appear in urine, no matter whether it be normal or pathological.<br>As a rule, amino-acids detected in urine of hepatic patients increase in number; especially in the jaundice-stage of acute hepatitis there can be ascertained several sorts of amino-acids, while in the reconvalescence they decrease in number showing tendency to become normal.<br>In cases with liver cirrhosis, detected amino-acids are of various number, only the appearance of amino-acids with large Rf is more remarkable than in those who suffer from hepatitis. This occurrence is neither concerned in existence of icterus nor ascites.<br>In cases with hepatic coma, some increase in number very much, others not so markedly. That is to say, patients suffering from hepatic coma do not always excrete high-degree amino-aciduria.<br>Number of amino-acids proved in hepatic cancer is relatively few, and there is no great difference between in cancer and innormal.<br>Number of amino-acids detected in cholecystitis and cholecystopathy fluctuates instablely. In above mentioned cases there can not be proved any special amino-acid appearing without fail.<br>Attitude of amino-acids in urine of rats which livers were damaged with various kinds of toxins, is similar to that of clinical cases.<br>High protein diet after administration of hepatic toxins is admitted as effective to prevent the appearance of a certain amino-acids in urine.

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