書誌事項
- タイトル別名
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- Biosensor Device with SPR Imaging Technique: The Design of High Density DNA Bio-tip
- SPRイメージング法のバイオセンサー応用:高密度集積型DNAマイクロアレイの開発
- SPR イメージングホウ ノ バイオセンサー オウヨウ コウミツド シュウセキガタ DNA マイクロアレイ ノ カイハツ
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抄録
We have developed a new methodology to fabricate high resolution DNA microarray (2,500-104 dots/cm2) in combination with micro contact printing (μ-CP) and SPR imaging. Novel COOH-terminated PEG-disulfides with p-carborane were synthesized to fabricate the first layer on gold substrates to achieve surface coupling reaction with amino-terminated DNA in high yield. The hybridization of the target-DNA modified gold nanoparticles on probe-DNA patterned surfaces was successfully demonstrated by the SPR imaging, where nonspecific adsorption was not observed to the array background. The gold nanoparticle arrays provide quite high contrast even at low surface coverage (∼10%) by the enhancement effect of optical signals based on nano-scale phenomena in the near field. This enhancement effect can be well demonstrated by the simulation based on Maxwell-Garnett (MG) theory and Fresnel's equation.
収録刊行物
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- 表面科学
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表面科学 27 (1), 21-26, 2006
公益社団法人 日本表面科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206459697664
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- NII論文ID
- 10017152092
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- NII書誌ID
- AN00334149
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- COI
- 1:CAS:528:DC%2BD28Xis1ahu7k%3D
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- ISSN
- 18814743
- 03885321
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- NDL書誌ID
- 7794577
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可