Inhibitory Effect of Aucubin Isolated from Eucommia ulmoides against UVB-Induced Matrix Metalloproteinase-1 Production in Human Skin Fibroblasts

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  • HO Jin-Nyoung
    Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
  • LEE Yoo-Hyun
    Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
  • LEE Yun-Dong
    Division of Food Contaminant, Korea Food and Drug Administration
  • JUN Woo-Jin
    Department of Food and Nutrition, Chonnam National University
  • KIM Hye-Kyung
    Department of Food and Biotechnology, Hanseo University
  • HONG Bum-Shik
    Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
  • SHIN Dong-Hoon
    Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
  • CHO Hong-Yon
    Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University

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  • Inhibitory Effect of Aucubin Isolated from<i>Eucommia ulmoides</i>against UVB-Induced Matrix Metalloproteinase-1 Production in Human Skin Fibroblasts

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Abstract

Of 30 herbal plants tested, the methanol extracts of Eucommia ulmoides (52%), Evodia officinalis (45%), and Pleuropterus multiflorus (41%) each showed a potent inhibitory effect on the matrix metalloproteinase-1 (MMP-1) production in ultraviolet B (UVB)-irradiated human fibroblasts. Aucubin was isolated as the MMP-1 inhibitor from E. ulmoides, and significantly suppressed the production of MMP-1 by nearly 57% compared to the control. It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging.

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