Inhibitory Effect of Aucubin Isolated from<i>Eucommia ulmoides</i>against UVB-Induced Matrix Metalloproteinase-1 Production in Human Skin Fibroblasts
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- HO Jin-Nyoung
- Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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- LEE Yoo-Hyun
- Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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- LEE Yun-Dong
- Division of Food Contaminant, Korea Food and Drug Administration
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- JUN Woo-Jin
- Department of Food and Nutrition, Chonnam National University
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- KIM Hye-Kyung
- Department of Food and Biotechnology, Hanseo University
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- HONG Bum-Shik
- Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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- SHIN Dong-Hoon
- Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
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- CHO Hong-Yon
- Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University
書誌事項
- タイトル別名
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- Inhibitory Effect of Aucubin Isolated from Eucommia ulmoides against UVB-Induced Matrix Metalloproteinase-1 Production in Human Skin Fibroblasts
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Of 30 herbal plants tested, the methanol extracts of Eucommia ulmoides (52%), Evodia officinalis (45%), and Pleuropterus multiflorus (41%) each showed a potent inhibitory effect on the matrix metalloproteinase-1 (MMP-1) production in ultraviolet B (UVB)-irradiated human fibroblasts. Aucubin was isolated as the MMP-1 inhibitor from E. ulmoides, and significantly suppressed the production of MMP-1 by nearly 57% compared to the control. It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (11), 2227-2231, 2005
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206472760192
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- NII論文ID
- 130000030500
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7729262
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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