Biosynthesis of Depudecin, a Metabolite of<i>Nimbya scirpicola</i>

  • TANAKA Masayasu
    Plant Protection Research Laboratory, Japan Tobacco Inc.
  • FUJIMORI Takane
    Plant Protection Research Laboratory, Japan Tobacco Inc.
  • NABETA Kensuke
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine

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  • Biosynthesis of Depudecin, a Metabolite of Nimbya scirpicola.

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  Feeding experiments of labeled acetates to Nimbya scirpicola proved the carbon origin of the straight-chain polyketide, depudecin. Differential hydrogen exchange of the 2H label originating from 2H labeled acetate along the polyketide chain occurred. In particular, the deuterium of an epoxide methine at C-3 was lost to a substantial extent in the formation of depudecin.<br>

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