Induction of Nitric Oxide Synthase by Saponins of Heat-Processed Ginseng
-
- KIM Ji Yeon
- College of Pharmacy, Sookmyung Women’s University
-
- LEE Hwa Jin
- College of Pharmacy, Sookmyung Women’s University
-
- KIM Ji Sun
- College of Pharmacy, Sookmyung Women’s University
-
- RYU Jae-Ha
- College of Pharmacy, Sookmyung Women’s University
この論文をさがす
抄録
Total saponin of heat-processed ginseng (TSHG) stimulated the production of nitric oxide (NO) in interferon-γ (IFN-γ)-primed macrophages through the increased expression of inducible nitric oxide synthase (iNOS). However, TSHG by itself had a very weak effect on the NO synthesis without IFN-γ priming. The saponins of white ginseng inhibited the NO production in lipopolysaccharide (LPS)/IFN-γ activated macrophages rather than the stimulation of NO production found in IFN-γ primed macrophages. The NO production by TSHG-stimulated macrophages was inhibited by the NOS inhibitor (NG-monomethyl-L-arginine (L-NMMA)) and nuclear factor-kappaB inhibitor (pyrrolidine dithiocarbamate (PDTC)). TSHG showed different serum-dependence from LPS on the activation of IFN-γ primed macrophages. This property of TSHG may explain the intensified anti-tumor properties of heat-processed ginseng through its immunostimulating activity.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 69 (5), 891-895, 2005
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206474794624
-
- NII論文ID
- 130000030317
-
- NII書誌ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 7322345
-
- PubMed
- 15914906
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可