Identification of<i>Acvr2a</i>as a Th17 Cell-Specific Gene Induced during Th17 Differentiation

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  • IHN Hyun-ju
    Division of Applied Life Science, PMBBRC, Gyeongsang National University
  • KIM Dong Hyeok
    Division of Applied Life Science, PMBBRC, Gyeongsang National University
  • MOON Chaerin
    Division of Applied Life Science, PMBBRC, Gyeongsang National University
  • CHUNG Jin Woong
    Department of Biological Science, Dong-A University
  • OH Sang-Seok
    Division of Applied Life Science, PMBBRC, Gyeongsang National University
  • SONG Hyunkeun
    Department of Anatomy and Tumor Immunology, Inje University College of Medicine
  • KIM Kwang Dong
    Division of Applied Life Science, PMBBRC, Gyeongsang National University

書誌事項

タイトル別名
  • Identification of Acvr2a as a Th17 Cell-Specific Gene Induced during Th17 Differentiation
公開日
2011
DOI
  • 10.1271/bbb.110436
公開者
公益社団法人 日本農芸化学会

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説明

IL-17-producing T lymphocytes have been found to comprise a distinct lineage of T helper cells (Th17 cells) that are major causes of autoimmune diseases such as EAE, RA, and IBD. In this study, we found that activin receptor type-2A (Acvr2a) is a gene induced during the differentiation of this effector cell lineage as compared with naïve T cells. The transcript of Acvr2a was not induced in Th1 and Th2 cells, and both TGF-β and IL-6 were required for the induction of Acvr2a. When the differentiation of Th17 cells was inhibited by all tarans retinoic acid (ATRA) which induces regulatory T cell (Treg) differentiation under Th17 differentiation conditions, expression of Acvr2a was also inhibited. Hence we propose that Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg.

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