Gender Difference in ICER Iγ transgenic diabetic mouse

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  • INADA Akari
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine SSP Stem Cell Unit, Kyushu University Graduate School of Medicine
  • ARAI Hidenori
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine
  • NAGAI Kojiro
    Department of Nephrology, Kyoto University Graduate School of Medicine
  • MIYAZAKI Jun-ichi
    Division of Stem Cell Regulation Research G6, Osaka University Graduate School of Medicine
  • YAMADA Yuichiro
    SSP Stem Cell Unit, Kyushu University Graduate School of Medicine
  • SEINO Yutaka
    SSP Stem Cell Unit, Kyushu University Graduate School of Medicine Kansai Electric Power Hospital
  • FUKATSU Atsushi
    Department of Nephrology, Kyoto University Graduate School of Medicine

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タイトル別名
  • Gender Difference in ICER I.GAMMA. Transgenic Diabetic Mouse
  • Gender Difference in ICER Ig transgenic diabetic mouse

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抄録

Few studies have been done to examine gender differences in diabetic mouse models. Here we examined a gender difference in Inducible cAMP Early Repressor (ICER) transgenic (Tg) mice, a diabetic mouse model. Longitudinal changes in diabetes and nephropathy were investigated in male and female Tg mice. Both male and female Tg mice developed severe diabetes early in life due to severely impaired insulin synthesis and decreased β-cell numbers, but only female Tg mice became less hyperglycemic later in life, and most female Tg mice did not develop diabetic nephropathy. Even some female Tg mice that remained hyperglycemic showed less renal expansion than age-matched male Tg mice. Thus the gender difference in the severity of diabetes and diabetic nephropathy was evident with age in this model. This study indicates that sex hormones may play a role in glucose metabolism in diabetic conditions.

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