Award Review : Deciphering the Roles of Glycan Processing in Glycoprotein Quality Control through Organic Synthesis
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- ITO Yukishige
- Synthetic Cellular Chemistry Laboratory, RIKEN ERATO, Japan Science and Technology Agency (JST), Glycotrilogy Project
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- TAKEDA Yoichi
- ERATO, Japan Science and Technology Agency (JST), Glycotrilogy Project
書誌事項
- タイトル別名
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- Deciphering the Roles of Glycan Processing in Glycoprotein Quality Control through Organic Synthesis
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Protein quality control (QC) in the endoplasmic reticulum (ER) comprises many aspects, including folding and transport of nascent proteins and degradation of misfolded proteins. Recent studies have revealed that high-mannose-type glycans play pivotal roles in the QC process. To gain knowledge of the molecular basis of this process with well-defined homogeneous compounds, we achieved a convergent synthesis of high-mannose-type glycans and their functionalized derivatives. A major part of our study focused on analyses of UDP-Glc: glycoprotein glucosyltransferase (UGGT) and ER glucosidase II, which play crucial roles in glycoprotein QC, to clarify their specificities. In addition, we established an in vitro assay system mimicking the in vivo condition, which is highly crowded due to the presence of various macromolecules.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 77 (12), 2331-2338, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206480258432
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- NII論文ID
- 130003381969
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC2c3ks1aksQ%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 025124017
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- PubMed
- 24317068
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可