多孔性微粒子を用いた薬物含有カプセルの調製　Ｖ　　多孔性セルロース微粒子をマトリックスとした薬物徐放性製剤の調製

DOI

書誌事項

タイトル別名
  • Preparation of capsules containing drug with porous particles. V. A sustained release system using porous cellulose spheres modified by grafting as matrices.

抄録

Polymer-coated spheres, obtained by the graft polymerization of methyl methacrylate (MMA) onto porous spheres based on cellulose by the pre-irradiation method, were used as matrices for the drug sustained release system for salicylic acid. The adsorption of salicylic acid was carried out by dipping the grafted spheres in a 50% aqueous ethanol solution containing salicylic acid. The amount of salicylic acid adsorbed (Q) increased proportionately with the percent graft of MMA (G) to the power of 2.9. Adsorption mechanism of salicylic acid could be expressed in term of Langmuir's adsorption isotherm. The ratio of constants for adsorption and desorption (k) and the saturated amount of salicylic acid adsorbed (Q0) were expressed as k=k1G and Q0=k2G2.4, respectively. These results indicate that the number of adsorption sites increased proportionately with the nth power of G as a results of the interaction of grafted poly (methyl methacrylate) (PMMA) and cellulose. Similar results were obtained with grafting of MMA, MMA-styrene (St), and MMA-methacrylic acid (MAc) in the presence of salicylic acid.

収録刊行物

  • 高分子論文集

    高分子論文集 44 (12), 885-891, 1987

    公益社団法人 高分子学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390001206523548800
  • NII論文ID
    130003837044
  • DOI
    10.1295/koron.44.885
  • ISSN
    18815685
    03862186
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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