Cystectomy in a patient with hereditary angioedema under treatment with C1 inhibitor: Report of a case

DOI Web Site 27 References
  • HAMADA Masakazu
    Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
  • OKUNAGA Syusuke
    Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
  • SHINTANI Motoko
    Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
  • AOTA Keiko
    Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
  • IMAI Tomoaki
    Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
  • YURA Yoshiaki
    Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry

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Other Title
  • C1インヒビター投与下に囊胞摘出術を行った遺伝性血管浮腫の1例
  • C1インヒビター投与下に嚢胞摘出術を行った遺伝性血管浮腫の1例
  • C1 インヒビター トウヨ カ ニ ノウホウテキシュツジュツ オ オコナッタ イデンセイ ケッカン フシュ ノ 1レイ

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Abstract

Hereditary angioedema （HAE） causes life-threatening laryngeal edema. The attack can be triggered,in general, by trauma, drugs, and infection. The risk after dental treatment and oral surgery is higher than that after other surgical procedures.We report on a 41-year-old woman with psoriasis arthropica and HAE who required tooth extraction and a cystectomy. To prevent angioedema, we injected tranexamic acid and C1 inhibitor before surgery. She underwent tooth extraction and a cystectomy under intravenous sedation. She was closely monitored during the night and was discharged from the hospital on the 4th day after operation. The patient received surgery successfully without any complications.The use of tranexamic acid, C1 inhibitor, and intravenous sedation is effective for preventing attacks of angioedema in HAE patients.

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