筋小胞体カルシウムＡＴＰａｓｅの構造と機能

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タイトル別名
  • Structure and function of Ca2+-ATPase of sarcoplasmic reticulum.
  • キン ショウホウタイ カルシウム ATPase ノ コウゾウ ト キノウ

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Sarcoplasmic reticulum Ca2+-ATPase is an integral membrane protein of Mr 110k and pumps Ca2+ against a large concentration gradient during relaxation of muscle. It is a member of Ptype ion pumps that include Na+, K+-ATPase and H+, K+-ATPase. Elaborated predictions of the secondary structure, assuming 10 transmembrane helices, have been proposed and a large body of experimental evidence seems to support this model. In particular, critical amino-acid residues implicated in the active transport have been identified by site-directed mutagenesis. Its unique three-dimensional structure has been revealed by cryo-electron microscopy. We now have some real structural basis to discuss about the active transport by P-type ion pumps.

収録刊行物

  • 生物物理

    生物物理 37 (1), 310-314, 1997

    一般社団法人 日本生物物理学会

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