書誌事項
- タイトル別名
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- Inhibitory effect of plasma on the growth of osteoblastic cells in culture
- バイヨウコツ ガ サイボウ ノ ゾウショク ニ タイスル ケッショウ ノ ソガイテキ サヨウ ニ ツイテ
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抄録
Platelet-rich plasma (PRP), which contains growth factors for osteoblasts, is clinically used to promote regeneration of osseous tissue. However, we found that human plasma dose-dependently inhibits the growth of cultured MC3T3-E1 osteoblastic cells. In this study, the characteristics of osteoblast inhibiting factor in plasma were investigated. The inhibitory effect on MC3T3-E1 cells was inactivated by pre-heating the plasma. The molecular weight of this factor was estimated to be more than 100-kDaltons by the ultrafiltration method, and the macromolecular fraction strongly inhibited the spreading of MC3T3-E1 cells. Moreover, pre-treatment with a serine protease inhibitor abrogated the inhibitory effect of this factor, suggesting that serine proteases have an important role in inhibiting the growth of MC3T3-E1 cells. These results suggest that the improved preparation of platelets to exclude osteoblast-inhibiting factor from PRP is needed for the efficient regeneration of osseous tissue.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 51 (2), 67-76, 2005
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206533033728
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- NII論文ID
- 10015546393
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 7289115
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可