書誌事項
- タイトル別名
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- Molecular Dynamics of Photo-electrical Transducing Proteins, Channelrhodopsins
- コウデン ヘンカン タンパクシツ チャネルロドプシン ノ ドウサ メカニズム
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抄録
Channelrhodopsins (ChRs), which were first identified from Chlamydomonas genome, are light-gated ion channels. Although ChRs are now widely applied for optogenetics in many biomedical fields such as neuroscience, the mechanisms are mostly unknown how the light absorption can gate the ion channel to be open. In this review, the photocurrent kinetics of ChRs is discussed in relation to the photocycle models. The glutamic acid residues uniquely present in B helix appear to regulate the flux of permeable cations. One of them, E97 would lie in the outer pore and interact with a cation to facilitate the dehydration.<br>
収録刊行物
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- 生物物理
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生物物理 52 (5), 226-229, 2012
一般社団法人 日本生物物理学会
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詳細情報 詳細情報について
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- CRID
- 1390001206534478080
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- NII論文ID
- 10030876985
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- NII書誌ID
- AN00129693
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- COI
- 1:CAS:528:DC%2BC38XhsFCnt7zF
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- ISSN
- 13474219
- 05824052
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- NDL書誌ID
- 024013787
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可