Molecular Nutritional Study on the Bioregulatory Effects of Green Tea Polyphenols

Tachibana Hirofumi

doi:10.4327/jsnfs.72.205

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緑茶ポリフェノールの生体調節作用に関する分子栄養学的研究
緑茶ポリフェノールの生体調節作用に関する分子栄養学的研究(令和元年度日本栄養・食糧学会学会賞受賞)
リョクチャポリフェノールノセイタイチョウセツサヨウニカンスルブンシエイヨウガクテキケンキュウ(レイワガンネンドニホンエイヨウ・ショクリョウガッカイガッカイショウジュショウ)
(JSNFS Award for Excellence in Research (2019))
(令和元年度日本栄養・食糧学会学会賞受賞)

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<p>Several beneficial health effects of green tea (Camellia sinensis) have been documented. These include anti-carcinogenic, anti-allergic, anti-hypertensive, anti-cardiovascular disease, and anti-hypercholesterolemic activities. The compounds responsible for these activities are a subgroup of polyphenols known as catechins. The major green tea catechins are (－)-epigallocatechin-3-gallate (EGCG) , (－)-epicatechin-3-gallate, (－)-epigallocatechin and (－)-epicatechin. Because EGCG is found only in tea from Camellia sinensis, EGCG is regarded as a characteristic constituent of green tea. EGCG is known to exhibit various biological and pharmacological properties. The 67-kDa laminin receptor (67LR) has been identified as a cell-surface EGCG receptor that confers EGCG responsiveness to many cells at physiological concentrations. 67LR has been shown to mediate the beneficial activities of this phytochemical, which include anti-cancer, anti-allergic, anti-inflammatory and insulin sensing modulation activities. MYPT1, eEF1A, protein phosphatase 2A, Akt, endothelial nitric oxide synthase, soluble guanylate cyclase, protein kinase Cδ, acid sphingomyelinase, sphingosine kinase 1 and cGMP are molecules known to be related to the bioregulatory effects of EGCG via 67LR. Some food factors potentiate the bioactivities of EGCG by modulating the EGCG-sensing pathway.</p>

Journal

Nippon Eiyo Shokuryo Gakkaishi

Nippon Eiyo Shokuryo Gakkaishi 72 (5), 205-210, 2019

Japan Society of Nutrition and Food Science

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