Successful treatment of POEMS syndrome-associated pulmonary hypertension with lenalidomide and dexamethasone therapy

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  • NAKAMURA Daisuke
    Department of Hematology and Immunology, Kagoshima University Hospital
  • HAYASHIDA Maiko
    Department of Hematology and Immunology, Kagoshima University Hospital
  • KUBOTA Kayoko
    Department of Cardiovascular Medicine, Kagoshima University Hospital
  • MATSUURA Eiji
    Department of Neurology and Geriatrics, Kagoshima University Hospital
  • TABUCHI Tomohisa
    Department of Hematology and Immunology, Kagoshima University Hospital
  • ARIMA Naosuke
    Department of Hematology and Immunology, Kagoshima University Hospital
  • INOUE Hirosaka
    Department of Hematology and Immunology, Kagoshima University Hospital
  • YOSHIMITSU Makoto
    Department of Hematology and Immunology, Kagoshima University Hospital
  • ISHITSUKA Kenji
    Department of Hematology and Immunology, Kagoshima University Hospital

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Other Title
  • レナリドミド・デキサメタゾン療法で改善したPOEMS症候群による肺高血圧症
  • レナリドミド ・ デキサメタゾン リョウホウ デ カイゼン シタ POEMS ショウコウグン ニ ヨル ハイ コウケツアツショウ

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Abstract

<p>POEMS syndrome is often complicated by pulmonary hypertension. The standard therapy for patients with POEMS syndrome is high-dose chemotherapy followed by autologous stem cell transplantation. However, the safety of high-dose chemotherapy for patients complicated with pulmonary hypertension remains unclear, and the optimal therapy for these patients is yet to be establishment. Herein, we report the case of a 54-year-old woman with POEMS syndrome accompanied by pulmonary hypertension. We successfully and safely performed lenalidomide and dexamethasone (Ld) therapy followed by high-dose chemotherapy and autologous stem cell transplantation, which improved her pulmonary hypertension. Thus, Ld can be considered as safe and effective for pulmonary hypertension with POEMS syndrome.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 59 (5), 489-491, 2018

    The Japanese Society of Hematology

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