Acute toxicity and outcomes of radiotherapy plus cetuximab in locally advanced head and neck cancer

  • Yamauchi Moriyasu
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Kawasaki Kanako
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Shimazaki Eriko
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Minesaki Akimichi
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Monji Mikio
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Suzuki Kumiko
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Shimazu Rintaro
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University
  • Kuratomi Yuichiro
    Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University

Bibliographic Information

Other Title
  • 当科における局所進行頭頸部癌に対するセツキシマブ併用放射線療法の早期有効性と有害事象の検討

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Abstract

We retrospectively reviewed the acute toxicity and efficacy of locally advanced head and neck cancer patients treated with radiotherapy plus cetuximab. Forty patients with head and neck cancer comprising 3 nasopharynx, 13 oropharynx, 21 hypopharynx and 3 larynx were analyzed. Clinical stages at diagnosis were Ⅲ in 8, ⅣA in 30 and ⅣB in 2 cases. The treatment completion rate was 92.5%. Grade 1 or 2 infusion reactions were observed in 2 patients. Three patients developed grade 2 interstitial lung disease. Grade 3 or higher adverse events were as follows: radiation dermatitis in 15, oral/pharyngeal mucositis in 14, aspiration pneumonia in 2, and laryngeal edema in 1 case. Response rates were 100% in nasopharynx, 92.3% in oropharynx, 83.3% in hypopharynx, 100% in larynx, and 89.2% in total. These findings of toxicity and efficacy are similar to those of recent publications.

Journal

  • Toukeibu Gan

    Toukeibu Gan 44 (3), 310-315, 2018

    Japan Society for Head and Neck Cancer

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