Trousseau症候群により多発脳梗塞を合併した中咽頭扁平上皮癌例

DOI Web Site Web Site 参考文献6件
  • 山崎 あやめ
    東京都保健医療公社大久保病院耳鼻咽喉科
  • 田邉 愛弓
    東京女子医科大学耳鼻咽喉科
  • 向井 昌功
    がん・感染症センター都立駒込病院耳鼻咽喉科・頭頸部腫瘍外科
  • 白倉 聡
    がん・感染症センター都立駒込病院耳鼻咽喉科・頭頸部腫瘍外科
  • 杉本 太郎
    がん・感染症センター都立駒込病院耳鼻咽喉科・頭頸部腫瘍外科

書誌事項

タイトル別名
  • A Case of Oropharyngeal Squamous Cell Carcinoma Complicated by Multiple Cerebral Infarctions due to Trousseau Syndrome
  • 臨床 Trousseau症候群により多発脳梗塞を合併した中咽頭扁平上皮癌例
  • リンショウ Trousseau ショウコウグン ニ ヨリ タハツ ノウコウソク オ ガッペイ シタ チュウ イントウ ヘンペイ ジョウヒ ガン レイ

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<p>Trousseau syndrome refers to a hypercoagulable state associated with malignancies. It is characterized by venous, and more rarely, arterial thrombosis. The most common pathology encountered in cases with arterial thrombosis is cerebral infarction, which is often multiple and diffusely distributed. Trousseau syndrome is commonly reported in cases of adenocarcinoma and is relatively rare in cases of squamous cell carcinoma. We report a rare case of multiple cerebral infarcts due to Trousseau syndrome in a patient with oropharyngeal squamous cell carcinoma.</p><p>A 61-year-old patient who had been treated for Stage IVB oropharyngeal carcinoma presented to our emergency department with double vision, nausea and difficulty in walking. Clinical examination revealed upbeat nystagmus and, raised D-dimer levels, and MRI showed multiple bilateral cerebral infarcts. Anticoagulant treatment was commenced, but the patient died one month after detection of the cerebral infarctions due to disease progression.</p><p>When encountering patients with multiple infarctions or recurrent thrombotic episodes, it is important to suspect Trousseau syndrome, and to carry out investigation to detect the responsible occult carcinomas and promptly commence treatment.</p>

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