Five Cases of Primary Malignant Lymphoma of the Paranasal Sinus

DOI Web Site 2 Citations 11 References Open Access
  • Sato Ryosuke
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University Department of Otolaryngology-Head & Neck Surgery, Hokuto Hospital
  • Kumai Takumi
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Kishibe Kan
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Takahara Miki
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Katada Akihiro
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Hayashi Tatsuya
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Harabuchi Yasuaki
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University

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Other Title
  • 副鼻腔原発悪性リンパ腫の5例

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<p>Primary malignant lymphoma rarely occurs in extranodal organs such as the paranasal sinus. However, the prognosis of the small number of patients with primary malignant lymphoma of the paranasal sinus is poor. Herein, we report five patients with this disease who were treated in our department. Three patients were male and two were female. The median age of the patients was 75 years, with an age range of 55 to 84 years. The maxillary sinus was involved in all cases. Histological examination revealed that three cases were diffuse large B-cell lymphoma, one was follicular lymphoma, and one was high-grade B-cell lymphoma, not otherwise specified. Based on the Ann Arbor system, two patients were classified as Stage IEA, two as Stage IIEA, and one as Stage IVEA. Three patients were treated with chemoradiotherapy, one with chemotherapy alone, and one with radiotherapy alone. All patients achieved complete response (CR) with initial treatment, but two relapsed. The overall CR rate was 80% with salvage treatment (chemotherapy or removal of skin metastasis). The high curability rate suggests that chemoradiation is effective for treatment of B-cell origin malignant lymphoma of the paranasal sinus.</p>

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