The initial symptom as a clinical parameter for rapid progression of HAM/TSP

DOI
  • Furuzono Mai
    Department of Neurology, Kagoshima University Hospital
  • Matsumoto Riku
    Department of Neurology, Kagoshima University Hospital
  • Mayumi Hanako
    Department of Neurology, Kagoshima University Hospital
  • Tashiro Yuichi
    Department of Neurology, Kagoshima University Hospital
  • Arata Hitoshi
    Department of Neurology, Kagoshima University Hospital
  • Yamano Yoshihisa
    Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine
  • Tanaka Masakazu
    Joint Research Center for Human Retrovirus Infection (Kagoshima University Campus)
  • Kubota Ryuji
    Joint Research Center for Human Retrovirus Infection (Kagoshima University Campus)
  • Matsuura Eiji
    Department of Neurology, Kagoshima University Hospital
  • Takashima Hiroshi
    Department of Neurology, Kagoshima University Hospital

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Other Title
  • HTLV-1 関連脊髄症における疾患進行の予測因子

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Description

<p>Background : While Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurological disease, the progression of the disease varies from person to person. While some blood or cerebrospinal fluid biomarkers for rapid progression of HAM/TSP have been reported, no clinical parameter associated with rapid progression of HAM/TSP has been identified except for older age. Purpose : We tried to find the initial symptom associated with rapid progression of the disease using registry data on patients ( n=527 ) enrolled in the Japanese HAM/TSP patient registry "HAM-net." We determined the periods from the onset of HAM/TSP to the age of wheelchair use in daily life of all the patients and compared the periods by their initial symptom. Result : Urinary disturbance as an initial symptom was significantly associated with slowly progression of HAM/TSP. Sensory disturbance as an initial symptom was significantly associated with rapid progression. Conclusion : The result showed that Initial symptoms could suggest the disease course of the patients with HAM/TSP.</p>

Journal

  • NEUROINFECTION

    NEUROINFECTION 25 (1), 146-, 2020

    Japanese Society for Neuroinfectious Diseases

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