A retrospective analysis of the relationship between the oral administration of probiotics during pregnancy and the Edinburgh postnatal depression scale at 1 month after delivery

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  • Kawakami Kosuke
    Department of Obstetrics and Gynecology, National Hospital Organization Kokura Medical Center
  • Yoshizato Toshiyuki
    Department of Obstetrics and Gynecology, School of Medicine, Kurume University
  • Okura Naofumi
    Department of Obstetrics and Gynecology, National Hospital Organization Kokura Medical Center

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  • 妊娠中プロバイオティクス経口投与と産後1カ月におけるエジンバラ産後うつ病自己評価との関連についての後方視的検討

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Abstract

<p> Objectives: To elucidate whether the oral administration of probiotics（PRO）during pregnancy is associated with the Edinburgh postnatal depression scale（EPDS）at 1 month after delivery.</p><p> Methods: The subjects were 916 cases who delivered in our hospital from March 2017 to December 2018, without psychological disorders and/or poor socioeconomic background. Survey using the EPDS was conducted at 1 month after delivery, on all subjects. There were 78 cases in which clostridium butyricum MIYAIRI 588 （CBM588）was administered for 2 weeks or longer during pregnancy for gastro-intestinal symptoms, including constipations, and such symptoms improved after initiation of administration. These cases were defined as a PRO administration group. The EPDS positive group which considered a high risk group for postnatal depression, were defined as those cases having high EPDS scores（≧ 9 points）and/or a score of #10 on the questionnaire of ≧ 1 point. The relationship between oral PRO admini-stration and clinical parameters was analyzed, and included the following 5 para-meters: EPDS positive, elderly pregnancy（≧ 35 years old）, maternal obesity（body mass index before pregnancy ≧ 28 kg/m2）, gestational diabetes mellitus and preterm birth（< 37 weeks）. The statistical analysis was conducted using multivariate logistic analysis with significance of P< 0.05.</p><p> Results: The related factors for the EPDS positive group were PRO administration during pregnancy, elderly pregnancy and preterm birth（< 37 weeks）.</p><p> Conclusion: There is a possibility that the oral PRO administration during pregnancy may have the positive effect of preventing postnatal depression.</p>

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