Cell-to-cell Variability Serves as Information not Noise

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  • WADA Takumi
    Center for iPS Cell Research and Application (CiRA), Kyoto University Department of Biological Sciences, Graduate School of Science, The University of Tokyo
  • HIRONAKA Ken-ichi
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo
  • KURODA Shinya
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo

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Other Title
  • 細胞のばらつきはノイズではなく情報である
  • サイボウ ノ バラツキ ワ ノイズ デワ ナク ジョウホウ デ アル

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<p>Organisms can adapt to the environment robustly despite large heterogeneity of cellular response. Heterogeneity of cellular responses has been regarded as noise, which reduces accurate information transmission. The heterogeneity consists of intracellular variation caused by stochasticity of biochemical reactions, and intercellular variation caused by differences in amounts of molecules (cell-to-cell variability). We found that intercellular variation increases gradualness of the multi-cellular dose-response (response diversity effect), resulting in increase of accuracy of information transmission. This “response diversity effect” is a novel mechanism that enables multi-cellular organisms to utilize cell-to-cell variability as information not noise.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 61 (5), 288-292, 2021

    The Biophysical Society of Japan General Incorporated Association

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