The Rheology of the Dynamic 3D Genome Organization
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- SHINKAI Soya
- RIKEN Center for Biosystems Dynamics Research (BDR)
Bibliographic Information
- Other Title
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- 3次元ゲノムDNA動態のレオロジー特性
- 3ジゲン ゲノム DNA ドウタイ ノ レオロジー トクセイ
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Description
<p>Chromatin fibers, as the substance of the genome, are biopolymers packed inside the cell nucleus. High-throughput chromosome conformation capture (Hi-C) techniques have revealed the 3D genome organization for over a decade. Meanwhile, live-cell imaging experiments have shown the dynamic nature of chromatin. To bridge the gap between genome 3D structure and dynamics, we have developed a computational method for deciphering Hi-C data by polymer modeling. Here we provide a way to uncover the rheological properties of the dynamic 3D genome organization.</p>
Journal
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- Seibutsu Butsuri
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Seibutsu Butsuri 61 (5), 293-297, 2021
The Biophysical Society of Japan General Incorporated Association
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Details 詳細情報について
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- CRID
- 1390008057583039488
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- NII Article ID
- 130008093158
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- NII Book ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL BIB ID
- 031785791
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed