Association of Chlamydophila pneumoniae DNA in Peripheral Blood Mononuclear Cells and IgA Antibody with Ath erosclerotic Diseases
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- Sawayama Yasunori
- Department of General Medicine, Kyushu University
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- Kikuchi Kensuke
- Department of General Medicine, Harasanshin hospital
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- Tatsukawa Masafumi
- Department of General Medicine, Harasanshin hospital
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- Hayashi Shin
- Department of General Medicine, Harasanshin hospital
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- Taira Yuuji
- Department of Cardiovascular Medicine, Harasanshin hospital
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- Furusyo Norihiro
- Department of General Medicine, Kyushu University
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- Hayashi Jun
- Department of General Medicine, Kyushu University
Bibliographic Information
- Other Title
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- PBMC 中の Chlamydophila pneumoniae DNA と Chlamydophila pneumoniae抗体との関連
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Abstract
An association has been demonstrated between Chlamydophila pneumoniae (C. pneumoniae) infection and atherosclerosis, but data on the relationship between C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) and antibodies to this organism are lacking. We investigated the C. pneumoniae DNA in PBMC by polymerase chain reaction (PCR) and C. pneumoniae IgG and IgA antibodies by enzyme-linked immunosorbent assay of 168 patients with atherosclerotic diseases and 27 controls (healthy control subjects). C. pneumoniae DNA was detected for 48/168 (29%) atherosclerosis patients, IgG for 79 (47%), and IgA for 98 (58%), whereas the corresponding numbers for the controls were 11 (41%), 13 (48%), and 7 (26%). There was no significant difference of the C. pneumoniae DNA positivity rate between the atherosclerosis patients and the controls. However, the C. pneumoniae IgA-positive rate was significantly higher for carotid atherosclerosis patients who had C. pneumoniae DNA in their PBMC than for those without it (74% vs. 18%, P < 0.05). Among the patients with coronary artery disease, the C. pneumoniae IgA antibody positive rate was significantly higher for the patients with DNA than for those without it (68% vs. 18%, P < 0.05). Our results suggest that a high C. pneumoniae IgA antibody titer and C. pneumoniae DNA positivity are associated with an increased risk of atherosclerotic diseases due to endovascular C. pneumoniae infection.
Journal
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- 福岡醫學雜誌
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福岡醫學雜誌 100 (9), 305-312, 2009-09-25
Fukuoka Medical Association
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Keywords
Details 詳細情報について
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- CRID
- 1390009224763349632
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- NII Article ID
- 120001757219
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- NII Book ID
- AN00215478
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- DOI
- 10.15017/16085
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- HANDLE
- 2324/16085
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- NDL BIB ID
- 10547473
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- ISSN
- 0016254X
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- PubMed
- 20077843
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Allowed