Comparative Study on the Actions of Toxin Extracts from Two Different Puffer Fishes on INa and Respiratory N-M Transmission in the Rat

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  • Yamamoto Sokatsu
    Graduate School of Medical Sciences, Kyushu University | Research Division for Life Sciences, Kumamoto Health Science University
  • Yoshimura Megumi
    Graduate School of Medical Sciences, Kyushu University | Research Division for Life Sciences, Kumamoto Health Science University
  • Iwata Satomi
    Research Division for Life Sciences, Kumamoto Health Science University
  • Matsuura Tatsuya
    Research Division for Life Sciences, Kumamoto Health Science University
  • Shin Min-Chul
    Research Division for Life Sciences, Kumamoto Health Science University
  • Yamaga Toshitaka
    Research Division for Life Sciences, Kumamoto Health Science University
  • Ito Yushi
    Research Division for Life Sciences, Kumamoto Health Science University
  • Akaike Norio
    Research Division for Life Sciences, Kumamoto Health Science University

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Other Title
  • ２種類の異なるフグより抽出した毒素成 分がラットCA1 ニューロンのNa 電流 と横隔膜での神経伝達に与える影響の比 較研究

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Abstract

We performed a comparative study on the effects of toxin extracts prepared from muscle and liver of two different puffer fishes on voltage dependent sodium current (INa), and compared the results with that of tetrodotoxin (TTX). The amount of toxin contained in the muscle or liver expressed as an amount of equipotent TTX differed in the two species (0.11-57.98 μg TTX/g tissue). In addition, we observed the effects of TTX or toxin extracts on the twitch contraction evoked by direct muscle stimulation of the rat hemidiaphragm or indirect phrenic nerve stimulations, in an attempt to understand the mechanisms involved in the transmission failure in the respiratory muscles, due to the ingestion of TTX bearing puffers, and found that TTX or toxin extracts preferentially affect motor nerve rather than muscle.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 101 (8), 173-181, 2010-08-25

    Fukuoka Medical Association

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