Synthesis of 9-Deoxycotylenol Derivatives Carrying a Fluorescent Chromophore

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During the course of our study on the structure-activity relationships of cotylenol, a plant-growth regulating diterpenoid, 9-deoxycotylenol has been found to retain the biological activities. Here, aiming to create new tools for targeting 14-3-3 proteins which are the biding proteins of this class of molecules and have recently been regarded to be the key regulatory proteins in the intracellular signal transductions, the synthesis of 9-deoxycotylenol derivatives carrying a fluorescent chromophore is reported.

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