Effect of Pregelatinized Brown Rice on Serum Cholesterol Levels in Obese Model Rats

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  • KOBAYASHI Ken-Ichi
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • YAMAGISHI Ayano
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • NAKAGAWA Toru
    Hitachi Health Management Center
  • MAEDA Yukie
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture Alpha Food Co., Ltd.
  • ITOH Arisa
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • YAMADA Chiharu
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • TOKUNAGA Kouki
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • FUJITA Saya
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • SUZUKI Tsukasa
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • TSUJII Yoshimasa
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • TAKANO Katsumi
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • YAMAMOTO Yuji
    Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture

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Other Title
  • アルファ化玄米が肥満モデルラットにおける血中コレステロール値に及ぼす影響
  • アルファカ ゲンマイ ガ ヒマン モデルラット ニ オケル ケッチュウ コレステロールチ ニ オヨボス エイキョウ

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Abstract

<p>　The purpose of this study was to evaluate the effects of pregelatinized brown rice on cholesterol metabolism in obesity using Zucker fatty (ZF) rats. Six-week-old male ZF rats and their lean littermates were divided into four experimental groups; (1) Lean: Zucker lean rats fed the AIN93G; (2) Control: ZF rats fed the AIN93G; (3) WR: ZF rats fed the AIN93G in which cornstarch was replaced with pregelatinized white rice; (4) BR: ZF rats fed the AIN93G in which cornstarch was replaced with pregelatinized brown rice. The rats were fed each diet for 10 weeks. Significant decreases in serum and hepatic cholesterol levels were observed in the WR and BR groups compared with the control group. In particular, this cholesterol-lowering effect was more remarkable for the BR than WR group. Gene expression of HMG-CoA reductase was significantly increased in the WR and BR groups relative to the control group. In addition, CYP7A1m RNA levels showed a significant increase in the BR compared with the WR group. Our results indicate that pregelatinized brown rice has a serum cholesterol-lowering effect in obesity.</p>

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