Insights from a patient with chronic lymphocytic leukemia complicating ALK<sup>+</sup> anaplastic large cell lymphoma

DOI Web Site 参考文献15件
  • Lin Wuqiang
    Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
  • Chen Xiuli
    Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
  • Cai Zhenjie
    Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
  • Zheng Heyong
    Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
  • Huang Hanxing
    Department of Pathology, the First Hospital of Putian City, Putian, Fujian, China.
  • Yang Huanxing
    Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
  • Hu Jianda
    Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
  • Zheng Jing
    Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
  • Asakawa Tetsuya
    Institute of Neurology, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong. China.

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<p>Chronic lymphocytic leukemia (CLL) that transforms into a more aggressive lymphoma has been termed Richter syndrome (RS). CLL with T-cell neoplasia is rarely reported; those with ALK+ anaplastic large cell lymphoma (ALCL) are also exceedingly rarely reported. A 63-year-old woman from the south of China presented with generalized lymphadenectasis and fever; she already had a prior diagnosis of CLL 9 years ago. As per her current diagnosis, it was CLL with ALK+ ALCL. The two-lymph node and bone marrow biopsies presented two types of cellular groups: i) left cervical lymph node biopsy suggested CLL (Ki67: 10%), along with bone marrow biopsy exhibited enhancement of the small lymphocytes (30%) with scant cytoplasm, round or irregular cell nuclei, and massive amounts of chromatin. Large cells (< 1%) that expressed CD30 and ALK were visible; The results of immunohistochemistry were as follows: CD20 (weak positive); PAX5 (positive); CD23 and CD5 (weak positive); and CD3, CD10, and CyclinD1 (negative); ii) left supraclavicular lymph node biopsy suggested ALK+ ALCL (Ki67: 70%). The final diagnosis was CLL with ALCL. The mechanisms of this condition are not fully understood, which might be associated with chronic stimulation of T cells by CLL cells along with immune dysfunction. </p>

収録刊行物

  • Intractable & Rare Diseases Research

    Intractable & Rare Diseases Research 11 (4), 196-201, 2022-11-30

    特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会

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