Plasmablastic lymphoma presenting clinical symptoms similar to plasmablastic myeloma

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  • NAKAYA Aya
    Department of Hematology, National Hospital Organization Osaka National Hospital
  • NAGATE Yasuhiro
    Department of Hematology, National Hospital Organization Osaka National Hospital
  • TODA Jun
    Department of Hematology, National Hospital Organization Osaka National Hospital
  • YAMASHITA Yudai
    Department of Hematology, National Hospital Organization Osaka National Hospital
  • HIROSE Yumiko
    Department of Central Laboratory and Surgical Pathology, National Hospital Organization Osaka National Hospital
  • MORI Kiyoshi
    Department of Central Laboratory and Surgical Pathology, National Hospital Organization Osaka National Hospital
  • SHIBAYAMA Hirohiko
    Department of Hematology, National Hospital Organization Osaka National Hospital

Bibliographic Information

Other Title
  • 形質芽球性骨髄腫と類似した臨床像を呈した形質芽球性リンパ腫
  • ケイシツ ガキュウセイ コツズイシュ ト ルイジ シタ リンショウゾウ オ テイシタ ケイシツ ガキュウセイ リンパシュ

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Description

<p>A 75-year-old man developed multiple head masses as well as a compression fracture. His blood test revealed elevated immunoglobulin G (IgG) protein levels, and immunofixation electrophoresis revealed the presence of monoclonal IgGκ. Furthermore, positron emission tomography/computed tomography revealed multiple bone lesions, although bone marrow examination revealed only 1.2% of plasma cells. Biopsy of a head mass led to the diagnosis of plasmablastic lymphoma (PBL), an aggressive B-cell lymphoma with plasma cell phenotypes but no B-cell antigen expression. Because the tumor cells have plasmablastic morphologies, it is difficult to distinguish PBL from plasmablastic myeloma, which is a subtype of multiple myeloma. Both diseases have similar immunophenotypes and clinical courses. In this case, PBL was finally diagnosed based on Epstein-Barr virus positivity, and the patient made a complete recovery after treatment with DA-EPOCH.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 64 (4), 260-264, 2023

    The Japanese Society of Hematology

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