Diffuse large B-cell lymphoma expressing high-level glyceraldehyde 3-phosphate dehydrogenase complicated with hypoglycemia

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  • HIRANO Shiho
    Department of Hematology, National Hospital Organization Nagoya Medical Center
  • IWAKOSHI Akari
    Department of Pathology, National Hospital Organization Nagoya Medical Center
  • IMAHASHI Nobuhiko
    Department of Hematology, National Hospital Organization Nagoya Medical Center
  • SAKAI Akihiro
    Department of Pathology, Nagoya University Graduate School of Medicine
  • HIRANO Daiki
    Department of Hematology, National Hospital Organization Nagoya Medical Center
  • SUZUKI Yasuhiro
    Department of Hematology, National Hospital Organization Nagoya Medical Center
  • ADACHI Tatsuya
    Department of Hematology, National Hospital Organization Nagoya Medical Center
  • NAGAI Hirokazu
    Department of Hematology, National Hospital Organization Nagoya Medical Center
  • IIDA Hiroatsu
    Department of Hematology, National Hospital Organization Nagoya Medical Center

Bibliographic Information

Other Title
  • 低血糖を合併したGAPDH高発現びまん性大細胞型B細胞リンパ腫
  • テイケットウ オ ガッペイ シタ GAPDH コウハツゲンビマンセイ ダイ サイボウガタ Bサイボウ リンパシュ

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Abstract

<p>A 69-year-old male patient was referred to our hospital for further examination of hypoglycemia, splenomegaly, and para-aortic lymphadenopathy. The patient was diagnosed with diffuse large B-cell lymphoma (DLBCL) by para-aortic lymph node biopsy. Hypoglycemia was refractory to glucose supplementation but improved shortly after chemotherapy. This situation suggested that hypoglycemia was caused by lymphoma. We compared the expression levels of glyceraldehyde 3-phosphate dehydrogenase, a glycolytic enzyme whose expression is positively correlated with the glycolytic activity of cells, between the current case and two cases of DLBCL without hypoglycemia to explore the possibility that hypoglycemia was due to intense glucose consumption by lymphoma cells through their high glycolytic activity. Results revealed substantially higher expression levels of glyceraldehyde 3-phosphate dehydrogenase in the current case than in DLBCL without hypoglycemia, suggesting that the glycolytic pathway was enhanced in the current case. These results implied that intense glucose consumption by lymphoma cells through their high glycolytic activity causes hypoglycemia.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 64 (7), 608-613, 2023

    The Japanese Society of Hematology

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