RAMP1シグナルの欠損は、食餌誘発性肥満と腸乳管を介した脂肪吸収を促進する

DOI Web Site

書誌事項

タイトル別名
  • Deletion of RAMP1 signaling enhances diet-induced obesity and fat absorption via intestinal lacteals in mice

抄録

<p>Lacteals play a critical role in the absorption and transport of dietary lipids into the circulation. We examined the role of signaling for receptor activity-modifying protein 1 (RAMP1), a subunit of CGRP receptor, in lacteal morphology and function in response to a high-fat diet (HFD). RAMP1 deficient (RAMP1–/–) or wild-type (WT) mice were fed a normal diet or HFD for 8 weeks. RAMP1–/– mice fed an HFD showed heavier body weights than WT mice fed an HFD, which was associated with high levels of total cholesterol, triglycerides, and glucose. HFD-fed RAMP1–/– mice had shorter length of lacteals and greater width of lacteals than HFD-fed WT mice. HFD-fed RAMP1–/– mice had lower gene expression levels of lymphatic endothelial cell markers including VEGFR3, and lymphatic vascular growth factor VEGF-C than HFD-fed WT mice. The concentration of the absorbed lipid tracer in HFD-fed RAMP1–/– mice was higher than that in HFD-fed WT mice. The zipper-like continuous junctions were predominant in HFD-fed WT mice, while the button-like discontinuous junctions were predominant in HFD-fed RAMP1–/– mice. These results suggest that deletion of RAMP1 signaling suppressed lacteal growth and VEGF-C/VEGFR3 expression and accelerated the uptake and transport of dietary fats through discontinuous junctions of lacteals, leading to excessive obesity.</p>

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ