Molecular mechanism of the cancer odor and development of the new cancer diagnostic system

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  • SONODA Hideto
    Department of General Surgery, Imari-Arita Kyoritsu Hospital Research and Development Center for Five-Sense Devices, Kyushu University Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • TANAKA Mitsuru
    Research and Development Center for Five-Sense Devices, Kyushu University Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • MATSUI Toshiro
    Research and Development Center for Five-Sense Devices, Kyushu University Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • OKI Eiji
    Research and Development Center for Five-Sense Devices, Kyushu University Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

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  • がんのにおい発生の分子機序解明と新しいがん診断法の開発
  • ガン ノ ニオイ ハッセイ ノ ブンシ キジョ カイメイ ト アタラシイ ガン シンダンホウ ノ カイハツ

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<p>We verified a screening method using canine scent detection of cancer and reported that it was possible to identify colorectal cancer with a sensitivity of 91% and a specificity of 99%, and that a distinctive odor appears when cancer develops. We identified the odorants produced by breast cancer cells and found that several moderate-volatile medium-chain fatty acids were present at high concentrations in the culture fluid derived from breast cancer cell lines. We reported that this may be related to the exhaled breath odor characteristic of cancer patients, which has been reported so far. Furthermore, breast cancer patients excrete more medium-chain fatty acids in their urine than normal subjects. We have confirmed that this is the case and are currently investigating the matter.</p>

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