Study on the Bioavailability and Functionality of Small Peptides

DOI IR (HANDLE) Web Site 29 References Open Access
  • Matsui Toshiro
    Department of Bioresources and Biosciences, Faculty of Agriculture, Graduate School, Kyushu University

Bibliographic Information

Other Title
  • 低分子ペプチドの吸収と生理機能に関する研究
  • (JSNFS Award for Excellence in Research (2024))
  • (令和6年度日本栄養・食糧学会学会賞受賞)

Search this article

Description

<p>It has been reported that peptides, condensed amino acids, may provide health benefits, such as anti-hypertensive, anti-diabetic, and anti-dementia effects. One successful TOKUHO product is a sardine peptide that can modulate high blood pressure. However, the bioavailability of bioactive peptides still remains unclear due to a lack of appropriate analytical assay systems. In order to detect absorbed analytes in a small volume of blood, highly sensitive analytical assays that allow detection at ＞pmol/mL-plasma, such as fluorescence-derivatization column-switching HPLC, amine-derivatization-LC-MS/MS, and MS imaging for visualization of tissue distribution have been developed. In this review, the bioavailability of small peptides as intact forms and their physiological potentials are discussed.</p>

Journal

References(29)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top