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- HIRAMATSU Hajime
- Medicinal Chemistry Research Laboratories, Tanabe Seiyaku Co., Ltd.
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- YAMAMOTO Atsushi
- Medicinal Chemistry Research Laboratories, Tanabe Seiyaku Co., Ltd.
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- KYONO Kiyoshi
- Medicinal Chemistry Research Laboratories, Tanabe Seiyaku Co., Ltd.
Bibliographic Information
- Other Title
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- ヒト由来ジペプチジルペプチダーゼIV(DPPIV)の結晶構造解析
- サイキン ノ ケンキュウ カラ ヒト ユライ ジペプチジルペプチダーゼ IV DPPIV ノ ケッショウ コウゾウ カイセキ
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Abstract
Human dipeptidyl peptidase IV (DPPIV) [EC 3.4.14.5] belongs to the prolyl oligopeptidase (POP) family, a member of the serine proteases. The crystal structure of DPPIV was determined at 2.6 Å resolution. The molecule consists of a unique eight-bladed β-propeller domain and a α/β-hydrolase domain. The large“cave”structure, which is thought to control the access of substrate, is found on the side of the β-propeller fold. Furthermore, the crystal structure of DPPIV in complex with diprotin A was determined at 2.2 Å resolution. The structure reveals the molecular interaction mechanism of diprotin A with DPPIV.
Journal
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- Nihon Kessho Gakkaishi
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Nihon Kessho Gakkaishi 47 (4), 261-267, 2005
The Crystallographic Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679063479168
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- NII Article ID
- 130000800520
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- NII Book ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL BIB ID
- 7473647
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed